최상운

인사말

최상운 교수

전문분야 |  푸드테라피
전화번호 | 02-3015-5333
E – mail | sang.choi@cha.ac.kr

학력

1980 M.D., Seoul National University College of Medicine
1984 Intern & Resident of Internal Medicine, Seoul National University Hospital
1988 Fellow of Gastroenterology, Seoul National University Hospital
1988 M.S. in Medical Science, Seoul National University
1992 Ph.D. in Medical Science, Seoul National University

 

경력

1984 – 1987 Army doctor
1988 – 1993 Director of Internal Medicine Seoul City Boramae Hospital affiliated to Seoul National University Hospital
1990 – 1994 Clinical Instructor and Assistant Professor Seoul National University College of Medicine, Seoul, Korea
1993 – 1999 Visiting Scientist and Research Associate Jean Mayer USDA Human Nutrition Research Center at Tufts University
1999 – 2007 Scientist II & III Jean Mayer USDA Human Nutrition Research Center at Tufts University
2002 – 2007 Assistant Professor Friedman School of Nutrition Science and Policy Tufts University
2006 – 2007 Visiting Professor University of Verona School of Medicine, Verona, Italy
2006 – Visiting Professor Yonsei University College of Human Ecology, Seoul, Korea
2007 – 2013 Scientist I Jean Mayer USDA Human Nutrition Research Center at Tufts University
2007 – 2013 Associate Professor Friedman School of Nutrition Science and Policy Tufts University
2013 – Adjunct Scientist Jean Mayer USDA Human Nutrition Research Center at Tufts University
2013 – Adjunct Professor Friedman School of Nutrition Science and Policy Tufts University
2013 – Adjunct Professor Department of Nutrition, University of Massachusetts, School of Public Health and Health Science
2013 – Full Professor, CHA University School of Medicine
2013 – Director, Clinical Genomic Center at Chaum Life Center
2016 – Director, Center for Global Health at Chaum Life Center

 

수상경력

2006 Director’s Scientific Recognition Award at the Jean Mayer USDA Human Nutrition Research Center at Tufts University
2008 The Mead Johnson Award from the American Society for Nutrition
2012 The Korean Nutrition Society Award co-sponsored by the American Society for Nutrition

[연구논문]

[CURRENT RESEARCH SUPPORT]

Korean Food Research Institute (PI), 01/01/2015-12/31/2017
Clinical investigation for the relationship between K-food and epigenetic patterns

California Walnut Commission (co-Principal Investigator), 07/01/2013-12/31/2017
Genetic and epigenetic effects of walnut on colon cancer stem cells

[PAST RESEARCH SUPPORT]

Ministry of Science, ICT and Future Planning (co-Investigator) 09/0/2014-08/31/2015
Bio-Synergy Research Project
Construction of a clinical DB based on multi-omics to discover and validate biomarkers

Tufts University (co-Investigator), 7/1/13 – 6/30/14
Host-microbiome interactions altering mRNA and metabolomic profiles in colonic carcinogenesis

California Walnut Commission (co-Investigator), 05/01/12-04/40/14
Epigenetic modulation in the brains of young and old rats by walnuts

Jean Mayer USDA Human Nutrition Research Center (Principal Investigator), 10/01/10-09/31/13
A pilot study for calorie restriction

Subcontract for the Canadian Institute of Health Research project (Principal Investigator), 10/10-08/13
Effects of prenatal folate exposure on DNA methylation in the newborn infants

NIH/NIA (R01) (Principal Investigator), 03/01/07-02/28/13
Effect of aging and folate on colonic carcinogenesis

NIH/NIDDK (R24) (co-Investigator), 07/15/10-06/30/11
Sex differences in adipose tissue biology and metabolic disease

USDA CSREES National Research Initiative (co-Investigator), 08/15/06-02/14/10
The effect of folate status on genetic/epigenetic stability and tumorigenicity

NIH/NIAAA (R21) (Principal Investigator), 09/30/06-08/31/10
Epigenetic effects of chronic alcohol consumption on colonic mucosa

Subcontract with NIH/NCI (Principal Investigator), 06/30/08-06/29/10
A nested case-control study of DNA markers of one-carbon metabolism and the risk of non-Hodgkin lymphoma and multiple myeloma in the PLCO study

Subcontract with NIH/NCI (Principal Investigator), 06/03/08-06/02/09
Genomic DNA methylation and biohazard associated carcinogenesis

NIH/NCI (R21) (co-Investigator), 07/01/06-06/30/08
The role of the extracellular calcium-sensing receptor in dietary Ca2+ chemoprevention

Interagency agreement between NCI and USDA (Principal Investigator), 08/01/05-09/30/06
A Screening Study of Colorectal Adenomas

USDA/ARS 58-1950-7-707 (co-Investigator), 10/01/2004-09/30/09
(renewed annually, competitively renewed every 5 years)
Cancer and Nutrition

Fondazione Cariverona, Italy (co-Investigator), 09/10/04-09/09/06
Epigenetic mechanisms and gene-nutrient interactions in acute lymphocyte leukemias

NCI R03 (Principal Investigator), 07/03/02-06/30/04
Effects of aging on folate metabolism in the colon

Jean Mayer USDA Human Nutrition Research Center (Principal Investigator), 01/01/02-09/31/02
Effects of aging and folate status on the profile of gene expression in the rat colonic mucosa

New England Medical Center Cancer Center (co-Investigator), 03/01/01-02/28/02 \
Folate metabolism in the human colorectal mucosa

Bioreliance (subcontract with the NCI) (co-Investigator), 04/01/01-03/31/02
Molecular markers of methylation status

USDA/ARS 53-195-4401 (co-Investigator), 10/01/1999 – 09/30/04
(renewed annually, competitively renewed every 5 years)
Cancer and Nutrition

Cancer Research Foundation of America (Principal Investigator), 07/15/99-01/15/02
Dietary folate in the prevention of colorectal carcinogenesis: molecular and biochemical effects in young and old rats.

[ORGINAL RESEARCH]
Kim J, Park S, An H, Choi JY, Choi MS, Choi SW, Kim SJ. Differential tissue-specific and pathway-specific anti-obesity effects of green tea and taeumjowitang, a traditional Korean medicine, in Mice. Journal of Cancer Prevention 22(3):147-158, 2017

Moruzzi S, Guarini P, Udali S, Ruzzenente A, Guglielmi A, Conci S, Pattini P, Martinelli N, Olivieri O, Tammen SA, Choi SW, Friso S. One-carbon genetic variants and the role of MTHFD1 1958G>A in liver and colon cancer risk according to global DNA methylation. PLoS One 12(10):e0185792, 2017

Yoon A, Tammen SA, Park S, Han SN, Choi SW. Genome-wide hepatic DNA methylation changes in high-fat diet-induced obese mice. . Nutrition Research Practice 11(2):105-113, 2017

Tammen SA, Park LK, Dolnikowski GG, Ausman LM, Friso S, Choi SW. Hepatic DNA hydroxymethylation is site-specifically altered by chronic alcohol consumption and aging. European Journal of Nutrition 56:535-544, 2017

Tammen SA, Park JE, Shin PK, Friso S, Chung J, Choi SW. Iron supplementation reverses the reduction of hydroxymethylcytosine in hepatic DNA associated with chronic alcohol consumption in rats. J Cancer Prevention 21:264-270, 2016

Moruzzi S, Udali S, Ruzzenente A, Guglielmi A, Guarini P, Martinelli N, Conci S, Mazzi F, Pattini P, Tammen SA, Olivieri O, Pizzolo F, Choi SW, Friso S. The RFC1 80G>A, among common one-carbon polymorphisms, relates to survival rate according to DNA global methylation in primary liver cancers. PLoS One 11:e0167534, 2016

Liu W, Crott JW, Lyu L, Pfalzer AC, Li J, Choi SW, Yang Y, Masom JB, Liu Z. Diet- and genetically-induced obesity produces alterations in the microbiome, inflammation and Wnt pathway in the intestine of APC+/1638N mice: comparisons and contrasts. Journal of Cancer 7:1780-1790, 2016

Lee J, Kim YS, Lee JH, Heo SC, Lee KL, Choi SW, Kim Y. Walnut phenolic extract and its bioactive compounds suppress colon cancer cell growth by regulating colon cancer stemness. Nutrients 8:439- 453, 2016

Chung J, Kim YS, Lee J, Lee JH, Choi SW, Kim Y. Compositional analysis of walnut lipid extracts and properties as an anti-cancer stem cell regulator via suppression of the self-renewal capacity. Food Science and Biotechnology 25: 623-629, 2016

Kim JE, Song D, Kim J, Choi J, Kim JR, Yoon HS, Bae JS, Han M, Lee S, Hong JS, Song D, Kim SJ, Son MJ, Choi SW, Chung JH, Kim TA, Lee KW. Oral Supplementation with Cocoa Extract Reduces UVB-Induced Wrinkles in Hairless Mouse Skin. Journal of Investigative Dermatology 136:1012-1021, 2016

Kim J, Kwon EY, Park S, Kim JR, Choi SW, Choi MS, Kim SJ. Integrative systems analysis of diet-induced obesity identified a critical transition in the transcriptomes of the murine liver and epididymal white adipose tissue. International Journal of Obesity (Lond) 40;338-45, 2016

Pfalzer AC, Parnell LD, Iyer L, Liu Z, Kane A, Chen O, Tai AK, Bowman TA, Obin M, Mason JB, Greenber A, Choi SW, Selhub J, Paul-Pottenplackel L, Crott J. Diet- and genetically-induced obesity differentially affect the fecal microbiome and metabolome in Apc1638N mice. PLOS ONE 18:e0135758, 2015

Pizzolo F, Friso S, Morandini F, Antoniazzi F, Zaltron C, Udali S, Gandini A, Cavarzere P, Salvagno G, Giorgetti A, Speziali G, Choi SW, Olivieri O. Apparent Mineralocorticoid Excess by a novel mutation and epigenetic modulation by HSD11B2 promoter methylation. Journal of Clinical Endocrinology and Metabolism 100:E1234-1241, 2015

Udali S, Guarini P, Moruzzi S, Ruzzenente A, Tammen SA, Guglielmi A, Conci S, Pattini P, Olivieri O, Corrocher R, Choi SW, Friso S. Global DNA methylation and hydroxymethylation differ in hepatocellular carcinoma and cholangiocarcinoma and relate to survival rate. Hepatology 62:496-504, 2015

Choi SW, Tammen SA, Liu Z, Friso S. A lifelong exposure to a Western-style diet, but not aging, alters global DNA methylation in mouse colon. Nutrition Research and Practice 9:358-363, 2015

Udali S, Guarini P, Ruzzenente A, Ferrarini A, Guglielmi A, Lotto V, Tononi P, Pattini P, Moruzzi S, Campagnaro T, Conci S, Olivieri O, Corrocher R, Delledonne M, Choi SW, Friso S. DNA methylation and gene expression profiles show novel regulatory pathways in hepatocellular carcinoma. Clinical Epigenetics 7:43-55, 2015

Bird JK, Ronnenberg AG, Choi SW, Du F, Mason JB, Liu Z. Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations. Journal of Nutrition 145:79-86, 2015

Pfalzer AC, Choi SW, Tammen SA, Park LK, Bottiglieri T, Parnell LD, Lamon-Fava S. S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages. Physiological Genomics 46:617-23, 2014

Tammen SA, Dolnikowski GG, Ausman LM, Liu Z, Kim KC, Friso S, Choi SW. Aging alters hepatic DNA hydroxymethylation, as measured by liquid chromatography/mass spectrometry. Journal of Cancer Prevention 19:301-308, 2014

Tammen SA, Dolnokowski GG, Ausman LM, Liu Z, Sauer J, Friso S, Choi SW. Aging and alcohol interact to alter hepatic DNA hydroxymethylation. Alcoholism: Clinical and Experimental Research 38:2178-2185, 2014

Friso S, Udali S, Guarini P, Pellegrini C, Pattini P, Moruzzi S, Girelli D, Pizzolo F, Martinelli N, Corrocher R, Olivieri O, Choi SW. Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk. Cancer Epidemiology, Biomarkers & Prevention 22:348-355, 2013

Iskandar AR, Liu C, Smith DE, Ernst H, Hu KQ, Choi SW, Ausman L, Wang XD.
β-Cryptoxanthin restores nicotine-reduced lung SIRT1 to normal levels and inhibits nicotine-promoted lung tumorigenesis and emphysema in A/J mice. Cancer Prevention Research (Phila) 6:309-320, 2013

Al Rajabi A, Booth SL, Peterson JW, Choi SW, Suttie JW, Shea MK, Miao B, Grusak MA, Fu X. Deuterium-labeled phylloquinone has tissue-specific conversion to menaquinone-3 among Fischer 344 male rats. Journal of Nutrition 142:841-845, 2012

Friso S, Lotto V, Choi SW, Girelli D, Pinotti M, Guarini P, Udali S, Pattini P, Pizzolo F, Martinelli N, Corrocher R, Bernardi F, Olivieri O. Promoter methylation in coagulation F7 gene influences plasma FVII concentrations and relates to coronary artery disease. Journal of Medical Genetics 49:192-189, 2012

Dawlaty MM, Ganz K, Powell BE, Hu YC, Markoulaki S, Cheng AW, Gao Q, Kim J, Choi SW, Page DC, Jaenisch R. Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development. Cell Stem Cell 9:166-175, 2011

Pizzolo F, Blom HJ, Choi SW, Girelli D, Guarini P, Martinelli N, Stanzial AM, MD, Corrocher R, Olivieri O, and Friso S. Folic acid effects on S-adenosylmethionine, S-adenosylhomocysteine and DNA methylation in patients with intermediate hyperhomocysteinemia. Journal of the American College of Nutrition 30:11-18, 2011

Liu Z, Ciappio ED, Crott JW, Brooks RS, Nesvet J, Smith DE, Choi SW, Mason JB. Combined inadequacies of multiple B vitamins amplify colonic Wnt signaling and promote intestinal tumorigenesis in BAT-LacZxApc1638N mice. FASEB Journal 25:3136-3145, 2011

Sie KKY, Medline A, van Weel J, Sohn KJ, Choi SW, Croxford R, Kim YI. Effect of maternal and postweaning folic acid supplementation on colorectal cancer risk in the offspring. Gut 60:1687-1694, 2011

Kim KC, Jang H, Sauer J, Zimmerly EM, Liu Z, Chanson A, Smith DE, Friso S, Choi SW. Folate supplementation differently affects uracil content in DNA in the mouse colon and liver. British Journal of Nutrition 105:688-693, 2011

Tong SY, Kim MK, Lee JK, Lee JM, Choi SW, Friso S, Song ES, Lee KB, Lee JP. Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. Cancer Causes Control 22:63-72, 2011

Al Rajabi A, Peterson J, Choi SW, Suttie J, Barakat S, Booth SL. Measurement of menadione in urine by HPLC. J Chromatogr B Analyt Technol Biomed Life Sci. 878:2457-2460, 2010

Sauer J, Jang H, Zimmerly EM, Kim KC, Liu Z, Chanson A, Smith DE, Mason JB, Friso S, Choi SW. Aging, chronic alcohol consumption and folate are determinants of genomic DNA methylation, p16 promoter methylation and the expression of p16 in the mouse colon. British Journal of Nutrition 104:24-30, 2010

Sohn KJ, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang YC, Cho RC, Yates Z, Lucock M, Chiang EP, Austin RC, Choi SW, Laird PW, Kim YI. The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification. International Journal of Cancer 124:1999-2005, 2009

Veeramachaneni S, Ausman LM, Choi SW, Russell RM, Wang XD. High dose lycopene supplementation increases hepatic CYP2E1 protein and inflammation in alcohol-fed rats. Journal of Nutrition 138:1329-1335, 2008

Liu Z, Choi SW, Crott JW, Smith DE, Mason JB. Multiple B-vitamin inadequacy amplifies alterations induced by folate depletion in p53 expression and its downstream effector MDM2. International Journal of Cancer 123:519-525, 2008.

Gissot M, Choi SW, Thompson RF, Greally JM, Kim K. Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation. Eukaryotic Cell 7:537-540, 2008

Friso S, Pizzolo F, Choi SW, Guarini P, Castagna A, Ravagnani V, Carletto A, Pattini P, Corrocher R, Olivieri O. Epigenetic control of 11-beta hydroxysteroid dehydrogenase 2 gene promoter is related to human hypertension. Atherosclerosis 199:323-327, 2008

Lim U, Flood A, Choi SW, Albanes D, Cross AJ, Schatzkin A, Sinha R, Katki HA, Cash B, Schoenfeld P, Stolzenberg-Solomon R. Genomic methylation of leukocyte DNA in relation to colorectal adenoma among asymptomatic women. Gastroenterology 134:47-55, 2008

Crott JW, Liu Z, Keyes MK, Choi SW, Jang H, Moyer MP, Mason JB. Moderate folate depletion modulates the expression of selected genes involved in cell cycle, intracellular signaling, and folate uptake in human colonic epithelial cell lines. Journal of Nutritional Biochemistry 19:328-335, 2008

Liu Z, Choi SW, Crott JW, Keyes MK, Jang H, Smith DE, Kim M, Laird PW, Bronson R, Mason JB. Mild depletion of dietary folate combined with other B vitamins alters multiple components of the Wnt pathway in mouse colon. Journal of Nutrition 137:2701-2708, 2007

Keys MK, Jang H, Mason JB, Liu Z, Crott JW, Smith DE, Friso S, Choi SW. Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. Journal of Nutrition 137:1713-1717, 2007

Friso S, Lamon-Fava S, Jang H, Schaefer EJ, Corrocher R, Choi SW. Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women. British Journal of Nutrition 97:617-621, 2007

Kim Y, Lian F, Yeum KJ, Chongviriyaphan N, Choi SW, Russell RM, Wang XD. The effects of combined antioxidant (beta-carotene, alpha-tocopherol and ascorbic acid) supplementation on antioxidant capacity, DNA single-strand breaks and levels of insulin-like growth factor-1/IGF-binding protein 3 in the ferret model of lung cancer. International Journal of Cancer 120:1847-1854, 2007

Jin CJ, Park HK, Cho YM, Pak YK, Lee KU, Kim MS, Friso S, Choi SW, Park KS, Lee HK. S-adenosyl-L-methionine increases skeletal muscle mitochondrial DNA density and whole body insulin sensitivity in OLETF rats. Journal of Nutrition 137;339-344, 2007

Crott JW, Liu Z, Choi SW, Mason JB. Folate depletion in human lymphocytes up-regulates p53 expression despite marked induction of strand breaks in exons 5-8 of the gene. Mutation Research 626:171-179, 2007

Choi SW, Keyes MK, Horrocks P. LC/ESI-MS demonstrates the absence of 5-methyl-2′-deoxycytosine in Plasmodium falciparum genomic DNA. Mol Biochem Parasitol 150:350-352, 2006

Yang AS, Doshi KD, Choi SW, Mason JB, Mannari RK, Gharybian V, Luna R, Rashid A, Shen L, Estecio MRH, Kantarjian HM, Garcia-Manero G, Issa JP. DNA methylation changes after 5-aza-2’-deoxycytidine therapy in patients with leukemia. Cancer Research 66:5495-5503, 2006

Gabriel HE, Liu Z, Choi SW, Crott J. Song BC, Mason J, Johnson E J. A comparison of carotenoids, retinoids and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus non-smokers. Cancer Epidemiology, Biomarkers & Prevention 15:993-999, 2006

Gabriel HE, Crott JW, Ghandour H, Dallal GE, Choi SW, Keyes MK, Jang H, Liu Z, Nadeau M, Johnston A, Mager D, Mason JB. Chronic cigarette smoking is associated with diminished folate status, altered folate distribution, and increased genetic damage in the buccal mucosa of healthy adults. American Journal of Clinical Nutrition 83:835-846, 2006

Friso S, Girelli D, Trabetti E, Olivieri O, Guarini P, Pignatti PF, Corrocher R, Choi SW. The MTHFR 1298A>C polymorphism and genomic DNA methylation in human lymphocytes. Cancer Epidemiology, Biomarkers & Prevention 14; 938-943, 2005

Choi SW, Friso S, Keyes MK, Mason JB. Folate supplementation increases the genomic DNA methylation in the liver of elder rats. British Journal of Nutrition 93; 31-35, 2005

Crott JW, Choi SW, Branda RF, Mason JB. Accumulation of mitochondrial DNA deletions is age, tissue and folate- dependent in rats. Mutation Research 570; 63-70, 2005

Choi SW, Friso S, Ghandour H , Bagley PJ , Selhub J , Mason JB. Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. Journal of Nutrition 134; 750-755, 2004

Crott JW, Choi SW, Ordovas JM, Ditelberg J, Mason JB. Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: Implications for carcinogenesis. Carcinogenesis 25; 69-76, 2004

Waly M, Olteanu H, Banerjee R, Choi SW, Mason JB, Parker BS, Sukumar S, Shim S, Sharma A, Benzecry JM, Power-Charnitsky VA, Deth RC. Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal. Molecular Psychiatry 9; 358-370, 2004

Choi SW, Friso S, Dolnikowski GG, Bagley PJ, Edmondson AN, Nadeau MR, Smith DE, Mason JB. Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific. Journal of Nutrition 133; 1206-1212, 2003

Lee YJ, Kang SW, Yang Ji, Choi YM, Sheen D, Lee EB, Choi SW, Song YW. Coagulation parameters and plasma total homocysteine levels in Bechet’s disease. Thrombosis Research 106; 19-24, 2002

Friso S, Choi SW, Dolnikowski GG, Selhub J. A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Analytical Chemistry 74; 4526-4531, 2002

Choumenkovitch SF, Selhub J, Bagley PJ, Maeda N, Nadeau MR, Smith DE, Choi SW. In the cystathionine beta-synthase knockout mouse, elevations in total plasma homocysteine increase tissue S-adenosylhomocysteine, but responses of S-adenosylmethionine and DNA methylation are tissue specific. Journal of Nutrition 132; 2157-2160, 2002

Ghandour H, Lin BF, Choi SW, Mason JB, Selhub J. Folate status and age affect the accumulation of L-isoaspartyl residues in rat liver proteins. Journal of Nutrition 132; 1357-1360, 2002

Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, Olivieri O, Jacques PF, Rosenberg IH, Corrocher R, Selhub J. A common mutation in the 5, 10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proceedings of the National Academy of Sciences USA 99; 5606-5611, 2002

Woodson K, Mason JB, Choi SW, Hartman T, Tangrea J, Virtamo J, Taylor P, Albanes D. Hypomethylation of p53 in peripheral blood DNA is associated with the development of lung cancer. Cancer Epidemiology, Biomarkers & Prevention 10; 69-74, 2001

Lathrop Stern L, Selhub J, Mason JB, Choi SW. Genomic DNA hypomethylation, a characteristic of most cancers, is present in peripheral leukocytes of individuals who are homozygous for the C677T polymorphism in the methylenetetrahydrofolate reductase gene. Cancer Epidemiology, Biomarkers & Prevention 9; 849-853, 2000

Kim YI, Shirwadkar S, Choi SW, Puchyr M, Wang Y, Mason JB. Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon. Gastroenterology 119; 151-161, 2000

Stickel F, Choi SW, Kim YI, Bagley PJ, Seitz HK, Russell RM, Selhub J, Mason JB. Effect of chronic alcohol consumption on total plasma homocysteine level in rats. Alcoholism: Clinical and Experimental Research 24; 259-264, 2000

Sohn KJ, Puchyr M, Salomon RN, Graeme-Cook F, Fung L, Choi SW, Mason JB, Medline A, Kim YI. The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer. Carcinogenesis 20; 2345-2350, 1999

Choi SW, Stickel F, Baik HW, Kim YI, Seitz HK, Selhub J, Mason JB. Chronic alcohol consumption induces genomic, but not p53-specific, DNA hypomethylation in rat colon. Journal of Nutrition 129; 1945-1950, 1999

Choi SW, Kim YI, Weitzel JN. Mason JB. Folate depletion impairs DNA excision repair in the colon of the rat. Gut 43; 93-99, 1998

Kim YI, Salomon RN, Graeme-Cook F, Choi SW, Smith DE, Dallal GE, Mason JB. Dietary folate protects against the development of macroscopic colonic neoplasms in a dose-responsive manner in rats. Gut 39; 732-740, 1996

Kim YI, Pogribny IP, Salomon RN, Choi SW, Smith DE, James SJ, Mason JB. Exon-specific DNA hypomethylation of the p53 gene of rat colon induced by dimethylhydrazine. Modulation by dietary folate. American Journal of Pathology 149; 1129-1137, 1996

Choi SW, Shane B, Selhub J. Effect of methotrexate and 5-fluorouracil on de novo thymidylate synthesis in human colon carcinoma cell line, Caco-2. Journal of Nutritional Biochemistry 7; 513-517, 1996

[저서]

 

Editor, Nutrient and gene interactions in cancer, CRC press LLC, Boca Raton, FL, 2006
Editor, Nutrients and epigenetics, CRC press LLC, Boca Raton, FL, 2009
Guest Editor, Molecular Aspect of Medicine, review volume on epigenetics, volume 34, issue 4, July/August 2013
Guest Editor, Molecular Aspect of Medicine, review volume on statin and diet interaction, volume 38, August 2014
Guest Editor, Molecular Aspect of Medicine, review volume on epigenetics and metabolism, 2017
Editorial Board Member, Frontiers in epigenetics, since 2011
Editorial Board Member, IUBMB Life, since 2012
Editor, BioFactors, since 2012-
Editorial Board Member, Journal of Cancer Prevention, since 2014
Editorial Board Member, Nutrition Research and Practice, since 2016
Editorial Board Member, Molecular Aspects of Medicine, since 2016