이부용

인사말

이부용교수

기능성식품 및 영양유전체학
전화번호 | 031-881-7155
Email | bylee@cha.ac.kr

​학력

고려대학교 식품공학과 ( 학사 )
고려대학교 일반대학원 식품공학과 ( 석사 )
고려대학교 일반대학원 식품공학과 ( 박사 )
미국 Georgia 주립대학 식품공학과, CFSQE(Center for Food Safety and Quality Enhancement)연구소 post-doc. 연수

 

주요경력

2004 – 현재 : CHA 의과학대학교 식품생명공학과 교수
2012 – 2014: CHA의과학대학교 산학협력단장 겸 연구처장
2002 – 2004 : 한국식품연구원 인삼연구단 단장
1989 – 2002 : 한국식품연구원 특용작물이용팀 팀장
1999 – 2004 : 한국식품연구원 농산물가공업체 기술 컨설턴트
1998 – 2001 : 한림대학교 특성화사업단 노화학전공 겸임교수

 

주요학회활동

1994-현재. 미국 IFT(International Food Technologist) Professional Member
2000.1–현재. 한국식품과학회 평의원
1999.1-1999.12 한국식품과학회 편집간사
2001.1-2002.12 한국식품과학회 편집자(Editor)
2004.1-2004.12한국식품과학회 정보간사
2003.1-현재. 고려인삼학회 평의원
2003.1-2004.12고려인삼학회 기획위원회 간사
2003.1-2004.12고려인삼학회 인삼제품연구위원회 위원장
2003.1-현재. 고려인삼포럼 정책연구위원
2006.1-현재. 한국식품영양과학회 평의원
2005.1–2005.12.31. 한국식품영양과학회 사업간사
2005.11-2007.10 한국응용생명화학회 국.영문지 편집위원
2013.1.1-2013.12.31. 한국식품영양과학회 간사장
2014.1.1-2015.12 한국식품영양과학회 이사
2017.1.1-2017.12.31. 한국식품영양과학회 부회장
2017.1.1-2018.12.31. 고려인삼학회 학술위원장
2019.1.1-2020.12.31. 고려인삼학회 산학협력위원장

 

주요대외활동

2006.9-현재. KOSEN(한민족과학기술자네트워크)전문가(식품분야)
2005.2-2007.2. 한국과학기술정보연구원(KISTI) 식품.의약분야 전문교열인
2005.3-2007.2. 보건의료기술진흥사업 식품벤처 및 중소기업 분야 연구과제 심의위원장
2005.9.–2007.8. 한국바이오벤처협회 바이오기술 심의위원
2005.7.28-2007.7.27식품의약품안전청 HACCP 적용기준 심의기구 심의위원
2008.1.1-2009.6.30. 학술진흥재단 생명과학단 Program Manager
2008.11-2010.12.31. 농진청 국립농업과학원 기능성식품과 겸임연구관
2008.10.1-2015.12.31. (재)경기대진테크노파크, “친환경 생물소재 위원회” 위원장
2013.7-2013.8: 산업통상자원부 산하 지역사업평가원 경영평가위원회 위원장
2014.6-2014.7: 산업부 산하 테크노파크 경영평가위원회 기관관리부분 반장
2015.1.-2017.1: 녹색인증심의위원회 위원(산업부 주관)
2014.1-2018.4.30. (재)강원지역사업평가단 이사
2017.12.1-2018.11.30. 서울바이오허브 지식공동체 전문위원(서울시)
2019.4.1.-2021.3.31. 특수용도식품 표시ㆍ광고 자율심의위원회 위원

 

수상경력

1998.11. 농림부장관 표창장, 농림부 (농수산물 가공산업 발전에 기여 관련)
2001.10 한국식품과학회, 학술진보상 (식품가공 및 물성분야 업적 관련)
2018.11.1. 오뚜기학술상 수상(기능성식품 연구분야)

[연구목표 및 분야(기능성식품 및 영양유전체학 연구실)]
본 실험실의 연구목표는 다음과 같다.
– 식품성분의 섭취가 건강 및 질병관련 유전자의 발현에 미치는 영향을 연구하며,
– 개인의 유전적 차이에 따라 식품 및 약품 성분에 대한 반응차이 등을 연구하여,
– 분자생물학적 지식을 기능성식품과 접목시킨 개인별 맟춤형 기능성식품 개발을 통하여 궁극적으로 인간의 건강수명 연장 및 삶의 질 향상에 기여하고자 함.
-항미반, 항당뇨, 항염증, 항산화에 효과적인 생리활성물질 발굴
-Co-culture를 통한 항비만, 항당뇨,항염증, 항산화 사이의 연관관계 구명
-천연물 성분의 대사증후군 개선 효과 구명 및 기능성식품소재화 연구

 

[최근 주요발표논문]

Kippeum Lee1, Yeon-Joo Lee, Kui-Jin Kim, Sungwoo Chei, Heegu Jin, Hyun-Ji Oh and Boo-Yong Lee*. Gomisin N from Schisandra chinensis ameliorates lipid accumulation and induces a brown fat-like phenotype through AMP-Activated Protein Kinase in 3T3-L1 adipocytes. International Journal of Molecular Sciences(IF:4.183). 21, 2153(2020)

 

Heegu Jin+, Kippeum Lee+, Sungwoo Chei, Hyun-Ji Oh, Kang-Pyo Lee, Boo-Yong Lee*. Ecklonia stolonifera Extract Suppresses Obesity by Promoting Lipolysis and Adipose Browning in High-Fat Diet-Induced Obese Mice. Cells(IF:5.656). 9, 871(2020)

 

Ji-Hyeon Song†, Kui-Jin Kim†, Sungwoo Chei, Young-Jin Seo, Kippeum Lee and Boo-Yong Lee*. Korean red and black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress. Journal of Ginseng Research(IF:5.151). 44, 267-273(2020)

 

Sungwoo Chei+, Ji-Hyeon Song+, Hyun-Ji Oh, Kippeum Lee, Heegu Jin, Sun-Hye Choi, Seung-Yeol Nah, Boo-Yong Lee*. Gintonin-Enriched Fraction suppresses Heat Stress-Induced Inflammation through LPA Receptor. Molecules(IF:3.060). 25,1019-1028(2020)

 

Sungwoo Chei, Ji-Hyeon Song, Young-Jin Seo, Kippeum Lee, Kui-Jin Kim,and Boo-Yong Lee*. Spirulina maxima extract prevents activation of the NLRP3 inflammasome by inhibiting ERK signaling. Scientific Reports(IF:4.011). 10, 2075(2020)

 

Kippeum Lee, Heegu Jin, Sungwoo Chei, Hyun-Ji Oh, Jeong-Yong Lee, Boo-Yong Lee*. Effect of Dietary Silk Peptide on Obesity, Hyperglycemia, and Skeletal Muscle Regeneration in High-fat Diet-Fed Mice. Cells(IF:5.656). 9, 377-395(2020)

 

Sunmin Park *, Ting Zhang, Jing Yi Qiu, Xuangao Wu, Jeong-Yong Lee, Boo-Yong Lee *.

Silk amino acid consumption improves anti-diabetic symptoms by potentiating insulin secretion and preventing gut microbiome dysbiosis in non-obese type 2 diabetic animals. Nutrients(IF:4.196). 12, 311-326(2020)

 

Kippeum Lee, Heegu Jin, Sungwoo Chei, Jeong-Yong Lee, Hyun-Ji Oh and Boo-Yong Lee*. Dietary Silk Peptide Prevents High-Fat Diet-Induced Obesity and Promotes Adipose Browning by Activating AMP-Activated Protein Kinase in Mice. Nutrients(IF:4.196). 12, 201(2020)

 

Sungwoo Che†, Hyun-Ji Oh†, Ji-Hyeon Song, Young-Jin Seo, Kippeum Lee, Heegu Jin1,Jae-Hoon Oh, and Boo-Yong Lee*. Magnolol Suppresses TGF-β–Induced Epithelial-to-Mesenchymal Transition in Human Colorectal Cancer Cells. Frontiers in Oncology(IF:4.250). 9, article752(2019)

 

Young-Jin Seo*; Heegu Jin*; Kippeum Lee; Ji-Hyeon Song; Sungwoo Chei; Hyun-Ji Oh; Jae-Hoon Oh; Boo-Yong Lee+. Cardamonin suppresses lipogenesis by activating protein kinase A-mediated browning of 3T3-L1 cells. Phytomedicine(IF:4.180). 65,153064(2019)

 

Kippeum Lee†,Young-Jin Seo, Ji-Hyoen Song, Sungwoo Chei, and Boo-Yong Lee*. Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes. Journal of Ginseng Research(IF:4.029). 43(4), 589-599(2019)

 

Sun-Il Choi, Jong Seok Lee, Sarah Lee, Bong-Yeon Cho, Seung-Hyun Choi, Wan-Sup Sim, Young-Cheul Kim, Boo-Yong Lee, Il-Jun Kang, and Ok-Hwan Lee. Protective Effects and Mechanisms of Pourthiaea villosa (Thunb.) Decne. Extract on Hydrogen Peroxide-Induced Skin Aging in Human Dermal Fibroblasts. JOURNAL OF MEDICINAL FOOD(IF:2.020). DOI: 10.1089/jmf.2018.4379

 

Young-Jin Seo, Kippeum Lee, Sungwoo Chei, Ji-Hyeon Song, Boo-Yong Lee*. Ishige okamurae Extract Ameliorates the Hyperglycemia and Body Weight Gain of db/db Mice through Regulation of the PI3K/Akt Pathway and Thermogenic Factors by FGF21. Marine Drugs(IF:3.772). 17(7), 407-419(2019)

 

Wan-Sup Sim, Sun-Il Choi, Bong-Yeon Cho, Seung-Hyun Choi, Xionggao Han, Hyun-Duk Cho, Seung-Hyung Kim, Boo-Yong Lee, Il-Jun Kang, Ju-Hyun Cho *, Ok-Hwan Lee*. Anti-obesity effect of extract from Nelumbo nucifera L., Morus alba L., and Raphanus sativus mixture in 3T3-L1 adipocytes and C57BL/6J obese mice. Foods(IF:3.011). 8, 170-188(2019)

 

JIAE PARK1,*, SUN-YOUNG LEE1,*, JEEHEUN SHON1, KOEUN KIM1, HYO JIN LEE1,

KYUNG AH KIM1, BOO-YONG LEE2, SEUNG-HUN OH1, NAM KEUN KIM3 &

OK JOON KIM1,3. Adalimumab improves cognitive impairment, exerts neuroprotective effects and attenuates neuroinflammation in an Ab1-40-injected mouse model of Alzheimer’s disease. Cytotherapy(IF:3.993). 21(6),671-682(2019)

 

Ji-Hyun Song†, Kui-Jin Kim†, Seo-Yun Choi, Eun-Jeong Koh, Jong Dae Park1, Boo-Yong Lee*. Korean ginseng extract ameliorates abnormal immune response through the regulation of inflammatory constituents in Sprague-Dawley rat subjected to environmental heat stress. Journal of Ginseng Research(IF:4.029). 43(2), 252-260(2019)

 

Ji-Hyeon Song†, Kui-Jin Kim†, Sungwoo Chei, Young-Jin Seo, Kippeum Lee and Boo-Yong Lee*. Korean red and black ginseng extracts, JP5 and BG1, prevent hepatic oxidative stress and inflammation induced by environmental heat stress. Journal of Ginseng Research. doi.org/10.1016/j.jgr.2018.12.005.

 

Young-Jin Seo, Kippeum Lee, Ji-Hyeon Song, Sungwoo Chei, Boo-Yong Lee*. Ishige okamurae Extract Suppresses Obesity and Hepatic Steatosis in High Fat Diet-induced Obese Mice. Nutrients. 10(11),1802-1815(2018)

 

Kippeum Lee†,Young-Jin Seo, Ji-Hyoen Song, Sungwoo Chei, and Boo-Yong Lee*. Ginsenoside Rg1 promotes browning by inducing UCP1 expression and mitochondrial activity in 3T3-L1 and subcutaneous white adipocytes. Journal of Ginseng Research. doi: 10.1016/j.jgr.2018.07.005.

 

Do-Un Kim+, Hee-Chul Chung+, Jia Choi+, Yasuo Sakai+, Boo-Yong Lee*. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: a Randomized, Double-Blind, Placebo-Controlled Study. Nutrients. 10(7),826-838(2018)

 

Su-Jung Ryu*, Jia Choi*, Jong Seok Lee, Hyeon-Son Choi, Kye-Yoon Yoon, Ji-Hyun Hwang, Kui-Jin Kim+, Boo-Yong Lee+. Compound K Inhibits the Lipopolysaccharide-Induced Inflammatory Responses in Raw 264.7 Cell Line and Zebrafish. Applied sciences. 8(6),924-935(2018)

 

Young-Jin Seo+, Kui-Jin Kim+, Jia Choi, Eun-Jeong Koh, Boo-Yong Lee*. Spirulina maxima Extract reduces Obesity through Suppression of Adipogenesis and Activation of browning in 3T3-L1 Cells and High-Fat Diet-induced Obese Mice. Nutrients. 10(6),712-726(2018)

 

Eun-Jeong Koh†, Kui-Jin Kim†, Jia Choi, Do-Hyung Kang, Boo-Yong Lee*. Spirulina maxima extract prevents neuronal cell death through BDNF activation due to amyloid beta 1-42 (Aβ1-42) induced neurotoxicity in PC12 cells. Neuroscience Letters. 673,33–38(2018)

 

Ji-Hyun Song†, Kui-Jin Kim†, Seo-Yun Choi, Eun-Jeong Koh, Jong Dae Park1, Boo-Yong Lee*. Korean ginseng extract ameliorates abnormal immune response through the regulation of inflammatory constituents in Sprague-Dawley rat subjected to environmental heat stress. Journal of Ginseng Research. doi.org/10.1016/j.jgr.2018.02.003

 

Chang-Kil Yoo1†,Ji-Hyun Hwang2†,Kippeum Lee2,Young-Jin Lee1,Kui-Jin Kim2*,and Boo-Yong Lee2*. Anti-inflammatory effects of moutan cortex radicis extract, paeoniflorin and oxypaeoniflorin through TLR signaling pathway in RAW264.7 cells. Journal of Food and Nutrition Research. 6(1),26-31(2018)

 

Sun-IL Choi, Jong Seok Lee, Sarah Lee, Jin-Ha Lee, Myoung-Lae Cho, Hee-Sun Yang, Joo hong Yeo, Jong-Yea Kim, Boo-Yong Lee, Il-Jun Kang, Ok-Hwan Lee*. Radical Scavenging-Linked Anti-adipogenic Activity of Alnus firma Extracts. International Journal of Molecular Medicine. 41(1),119-128(2018)

 

Seo-Yun Choi†, Kui-Jin Kim†, Ji-Hyeon Song, and Boo-Yong Lee*. Ginsenoside Rg5 prevents apoptosis by modulating HO-1/Nrf2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells. Journal of Ginseng Research. 42(2),225-228(2018)

 

Jia Choi†,Su-Jung Ryu†,Kui-Jin Kim, Hyung-Min Kim2, Hee-Chul Chung2, and Boo-Yong Lee*. Single, 14 Days and 13 Weeks Repeated Dose Toxicity Studies of Daily Oral Gelidium elegans Extract Administration to Rats. Molecules. 23(1),217-235(2018)

 

Jia Choi†, Kui-Jin Kim†, Eun-Jeong Koh, and Boo-Yong Lee*. Gelidium elegans extract ameliorates type 2 diabetes mellitus through the regulation of MAPK and PI3K/Akt signaling. Nutrients. 10(1),51-64(2018)

 

Kui-Jin kim, Jin-Ha, Boo-Yong Lee, Lee, Ok-Hwan Lee. Optimized Cirsium setidens Nakai Fermented by Lentinula edodes Attenuates Lipid Accumulation by Regulating Fatty Acid Oxidation-mediated Lipolysis in 3T3-L1 Cells and High Calorie Diet-induced Obese Zebrafish. Journal of Food and Nutrition Research. 5(6):354-6, 2017-

 

Ji-Hyun Hwang, Kui-Jin Kim, Boo-Yong Lee. Crude Ecklonia cava Flake Extracts Attenuate Inflammation through the Regulation of TLR4 Signaling Pathway in LPS-Induced RAW264. 7 Cells. Molecules. 22(5):777, 2017

 

Young-Jin Seo, Kui-Jin Kim, Eun-Jeong Koh, Jia Choi, Boo-Yong Lee. Anti-adipogenesis mechanism of pterostilbene through the activation of heme oxygenase-1 in 3T3-L1 cells. Phytomedicine. 33:7-13, 2017

 

Eun-Jeong Koh, Kui-Jin Kim, Young-Jin Seo, Jia Choi, Boo-Yong Lee. Modulation of HO-1 by Ferulic Acid Attenuates Adipocyte Differentiation in 3T3-L1 Cells. Molecules. 22(5):745, 2017

 

Jia Choi, Kui-Jin Kim, Eun-Jeong Koh, Young-Jin Seo, Boo-Yong Lee. Gelidium elegans Regulates Blood Glucose Homeostasis in ICR Mice. Journal of Food and Nutrition Research. 5(4):274-8, 2017

 

Jia Choi, Kui-Jin Kim, Eun-Jeong Koh, Boo-Yong Lee. Gelidium elegans Regulates the AMPK-PRDM16-UCP-1 Pathway and Has a Synergistic Effect with Orlistat on Obesity-Associated Features in Mice Fed a High-Fat Diet. Nutrients. 9(4):342, 2017

 

Myo Jin Kwon, Kui-Jin Kim, Byun-Woo Yang, Boo-Yong Lee, Hyoung Chun Kim, Sung Kwon Ko. Optimal Conditions for Extracting the Ginsenosides Rg3, Rg5, and Rk1 from Black Ginseng. Journal of Food and Nutrition Research. 5(3):176-9, 2017

 

Yeon-Joo Lee, Ji-Hyun Hwang, Kui-Jin Kim, Boo-Yong Lee. Ecklonia cava-derived Polysaccharide Prevent Hydro Peroxide-induced Oxidative Stress and Neurotoxicity in Human Microglial HMO6 Cells. Journal of Food and Nutrition Research. 5(3):187-90, 2017

 

Seo-Yun Choi, Kui-Jin Kim, Ji-Hyeon Song, Boo-Yong Lee. Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells. Journal of Ginseng Research. DOI: 10.1016/j.jgr.2017.02.002, 2017

 

Eun-Jeong Koh, Kui-Jin Kim, Jia Choi, Hui-Jeon Jeon, Seo Min-Jung Seo, Boo-Yong Lee. Ginsenoside Rg1 suppresses early stage of adipocyte development via activation of C/EBP homologous protein-10 in 3T3-L1 and attenuates fat accumulation in high fat diet-induced obese zebrafish. Journal of ginseng research. 41(1):23-30, 2017

 

Yeon-Joo Lee, Min-Jung Seo, Ok-Hwan Lee, Kui-Jin Kim, Boo-Yong Lee. Hesperetin inhibits lipid accumulation and ROS production during adipocyte differentiation in 3T3‐L1 cells. Journal of Food Biochemistry. 41(3), 2017

 

Jia Choi, Kui-Jin Kim, Eun-Jeong Koh, Boo-Yong Lee. Altered gelidium elegans extract-stimulated beige-like phenotype attenuates adipogenesis in 3t3-l1 cells. Journal of Food and Nutrition Research. 4(7):448-53, 2016

 

Min-Jung Seo, Young-Jin Seo, Cheol-Ho Pan, Ok-Hwan Lee, Kui-Jin Kim†, Boo-Yong Lee†. Fucoxanthin Suppresses Lipid Accumulation and ROS Production During Differentiation in 3T3-L1 Adipocytes. Phytotherapy Research. 30, 1802–1808,2016

 

Kui-Jin Kim, Jia Choi, Boo-Yong Lee. Evaluation of the genotoxicity of Gelidium elegans extract in vitro and in vivo. Journal of Food and Nutrition Research. 4(10),653-657,2016

 

Kui-Jin Kim*, Sungwoo Chei*, Seo-Yun Choi, Ok-Hwan Lee, Boo-Yong Lee+. Pterostilbene activates the GRP78-elF2ɑ-ATF3 cascade of ER stress and subsequently induces apoptosis in HCT116 cells. Journal of Functional Foods. 26(10),539–547,2016

 

Jia Choi†, Kui-Jin Kim†, Eun-Jeong Koh and Boo-Yong Lee. Altered Gelidium elegans extract-stimulated beige-like phenotype attenuates adipogenesis in 3T3-L1 cells. Journal of Food and Nutrition Research. 4(7),448-453,2016

 

Jia Choi*, Kui-Jin Kim*, Byung-Hak Kim, Eun-Jeong Koh, Min-Jung Seo, Boo-Yong Lee+. 6-Gingerol suppresses adipocyte-associated Inflammation in vitro and in high fat diet-induced obese zebrafish. Planta Medica. 82: 1–8,2016

 

Ji-Hyeon Song§, Kui-Jin Kim§, Boo-Yong Lee*. Silibinin suppresses mediators of Inflammation through the inhibition of TLR4-TAK1 pathway in LPS-induced RAW264.7 cells. Journal of Food and Nutrition Research. 4(8),515-521,2016

 

Sung Gi Kim1,†, Kui-Jin Kim2,†, Yun Min Nam1,3, Shin Jung Kim3, Byung Ok Im4, Boo-Yong Lee2,*, and Sung Kwon Ko1,3,*. Microwave heating rapidly alters ginsenoside composition of fresh ginseng (Panax ginseng CA Meyer). Journal of Food and Nutrition Research. 4(6), 394-399,2016

 

MyoungLae Cho, Gi-Hae Shin, Jae-Min Kim, Jin-Ha Lee, Sun-Ok Park, Sang-Jong Lee, HyunMu Shin, Boo-Yong Lee, Il-Jun Kang, Ok-Hwan Lee. Acute and subchronic (13-week) toxicity of fermented Acanthopanax koreanum extracts in Sprague Dawley rats. Regulatory Toxicology and Pharmacology. 77, 93-99,2016

 

Yeon-Joo Lee, Kye-Yoon Yoon, Ok-Hwan Lee, Kui-Jin Kim, and Boo-Yong Lee. Polyphenol extracted from Ecklonia cava increases insulin-mediated glucose uptake in 3T3-L1 cells and reduces fasting blood glucose levels in male diabetic C57BL/KsJ db/db mice. Journal of Food and Nutrition Research. 4(2), 126-130, 2016

 

Ji-Hyun Hwang, Kui-Jin Kim, Su-Jung Ryu, and Boo-Yong Lee. Caffeine prevents LPS-induced inflammatory responses in RAW264.7 cells and zebrafish. Chemico-Biological Interactions. 248:1-7, 2016

 

Eun-Jeong Koh, Kui-Jin Kim, Jia Choi, Hui Jeon Jeon, Min-Jung Seo, Boo-Yong Lee. Ginsenoside Rg1 suppresses Early Stage of Adipocyte Development via Activation of CHOP10 in 3T3-L1 and attenuates Fat Accumulation in High fat Diet-induced Obese Zebrafish. Journal of Ginseng Research. 10.1016/j.jgr.2015.12.005

 

Hui-Jeon Jeon, Kye-Yoon Yoon, Hyeon son choi, Kui-Jin Kim, Boo-Yong Lee. Seapolynol and Dieckol improve Insulin Sensitivity through regulation of Pi3K Pathway in C57BL/KsJ-db/db Mice. Journal of Food and Nutrition Research. 3(10), 648-652,2015

 

Kye-Yoon Yoon, Kui-Jin Kim, Hyung-Sun Youn, Sei-Ryang Oh and Boo-Yong Lee. Brazilin suppresses inflammation via the down-regulation of IRAK4 in LPS-stimulated Raw264.7 macrophage. Journal of Food and Nutrition Research. 3(9), 575-580,2015

 

Kui-Jin Kim, Kye-Yoon Yoon, Hyung-Sun Youn, Sei-Ryang Oh and Boo-Yong Lee. Brazilein suppresses inflammation through inactivation of IRAK4-NF-κB pathway in Raw264.7 macrophage cell. International Journal of Molecular Sciences. 16(11),27589-27598, 2015

 

Kui-Jin Kim, Kye-Yoon Yoon, Hee-Do Hong, Boo-Yong Lee. Role of the Red Ginseng in Defence Against the Environmental Heat Stress in Sprague Dawley Rat. Molecules.

20(11), 20240-20253, 2015

 

Hui-Jeon Jeon, Hyeon-Son Choi, Yeon-Joo Lee, Ji-Hyun Hwang, Ok-Hwan Lee, Min-Jung Seo, Kui-Jin Kim, Boo-Yong Lee. Seapolynol extracted from Ecklonia cava inhibits adipocyte differentiation in vitro and decreases fat accumulation in vivo. Molecules.  20(12), 21715–21731, 2015

 

Yeon-Joo Lee,Hyeon-Son Choi,Min-Jung Seo, Hui-Jeon Jeon, Kui-Jin Kim, Boo-Yong Lee. Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and Zebrafish. Food & Function. 6(8),2824-2833, 2015

 

Min-Jung Seo, Yeon-Joo Lee, Ji-Hyun Hwang, Kui-Jin Kim, Boo-Yong Lee. The inhibitory effects of quercetin on obesity and obesity-induced inflammation by regulation of MAPK signaling. The Journal of Nutritional Biochemistry. 26(11),1308-1316, 2015

 

Hyeon-Son Choi, Hui-Jeon Jeon,Ok-Hwan Lee,and Boo-Yong Lee. Dieckol, a major phlorotannin in Eckloniacava, suppresses lipid accumulation via AMPKα activation in the adipocytes of high-fat diet-fed zebrafish and mice: Inhibition of early adipogenesis via cell cycle arrest and AMPKa activation. Molecular Nutrition and Food Research. 59(8), 1458–1471, 2015

 

Jong Seok Lee, Young-Hyun Kim, Dan-Bi Kim, Gi-Hae Shin, Jin-Ha Lee, Ju-Hyun Cho, Boo-Yong Lee, Ok-Hwan Lee. Acute and subchronic (28 days) oral toxicity studies of Codonopsis lanceolata extract in Sprague–Dawley rats. Regulatory Toxicology and Pharmacology. 71,491-497, 2015

 

Mi-Seon Woo, Hyeon-Son Choi, Min-Jung Seo, Hui-Jeon Jeon and Boo-Yong Lee. Ellagic acid suppresses lipid accumulation by suppressing early adipogenic events and cell cycle arrest.  Phytotherapy Research. 29:398-406, 2015

 

Su-Jung Ryu, Hyeon-Son Choi, Kye-Yoon, Ok-Hwan Lee, Kui-Jin Kim, and Boo-Yong Lee. Oleuropein suppresses LPS-induced inflammatory responses in RAW 264.7 cell and zebrafish. J Agric Food Chem. 63(7),2098-105, doi:10.1021/jf505894b, 2015

 

Ok-Hwan Lee, Jea Hwan Kim, Young Hyun Kim, Young Jun Lee, Jong Seak Lee, JuHyun Jo, Bong Gyun Kim, Jea Kag Lim, and Boo-Yong Lee. Nutritional Components and Physiological Activities of Cirsium setidens Nakai. J Korean Soc Food Sci Nutr. 43(6), 791~789, 2014

 

Jong Seok Lee, Kui-Jin Kim, Young-Hyun Kim, Dan-Bi Kim, Gi-Hae Shin, Ju-Hyun Cho, Bong Kyun Kim, Boo-Yong Lee and Ok-Hwan Lee. Codonopsis lanceolata Extract Prevents Diet-Induced Obesity in C57BL/6 Mice. Nutrients. 6, 4663-4677, doi:10.3390/nu6114663, 2014

 

Hyeon-Son Choi, Hui-Jeon Jeon, Ok-Hwan Lee, Boo-Yong Lee. Indole-3-carbinol (I3C) inhibits adipogenesis by regulating cell cycle and AMPKα signaling. Biochimie. 104,127-136, 2014

 

Sang-Yoon Lee, Yeon-Ji Jo, Mi-Jung Choi, Boo-Yong Lee, Jong-Kwon Han, JaeKag Lim, and Jae-Wook Oh. Effect of Coating Method on the Survival Rate of L. plantarum for chicken Feed. Korean J. Food Sci. Nut., 34(2), 230-237, 2014

 

Min-Jung Seo, Hyeon-Son Choi, Hui-Jeon Jeon, Mi-Seon Woo, Boo-Yong Lee. Baicalein inhibits lipid accumulation by regulating early adipogenesis and m-TOR signaling. Food and Chemical Toxicology. 67C:57-64, 2014

 

Hui-Jeon Jeon, Min-Jung Seo, Hyeon-Son Choi, Ok-Hwan Lee, Boo-Yong Lee. Gelidium elegans, an edible red seaweed, and its flavonoids inhibit lipid accumulation and production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in 3T3-L1 and RAW264.7 cells. Phytotherapy Research. DOI: 10.1002/ptr.5186, 2014

 

Young-Jun Lee, Dan-Bi Kim, Jong Seok Lee , Ju-Huyn Cho, Bong Kyun Kim , Hyeon-Son Choi, Boo Yong Lee, Ok-Hwan Lee. Antioxidant Activity and Anti-Adipogenic Effects of Wild Herbs Mainly Cultivated in Korea. Molecules. 18(10), 12937-12950, 2013

 

Young Jun Lee, Ohan Taek Han1, Hyeon-Son Choi, Boo Yong Lee, Hyun-Jung Chung, and Ok-Hwan Lee. Antioxidant and Anti-adipogenic Effects of PineXol®. KOREAN J. FOOD SCI. TECHNOL., 45(1), 97-103, 2013

 

Jae Min Kim, Hong Mei Zheng, Boo Yong Lee, Woon Kyu Lee, and Don Haeng Lee. Anti-Helicobacter pylori Properties of GutGardTM. Prev. Nutr. Food Sci., 18(2),104-110, 2013

 

Seok-Yeong Yu, Young-Jun Lee, Ho-seong Song, Hee-Do Hong, jeong-Ho Lim, Hyeon-Son Choi, Boo-Yong Lee, Suk-Nam Kang, Ok-Hwan Lee. Antioxidant Effects and Nitrite Scavenging Ability of Extract from Acanthopanax cortex Shoot. Korean J. Food&Nutri., 25(4),793-799,2013

 

Min-Jung Seo, Ok-Hwan Lee, Hyeon-Son Choi, and Boo-Yong Lee. Extract from Edible Red Seaweed (Gelidium amansii) Inhibits Lipid Accumulation and ROS Production during Differentiation in 3T3-L1 Cells. Preventive Nutrition and Food Science, 17(2),129-135,2012

 

Hui-Jeon Jeon, Hyeon-Son Choi, OK-Hwan Lee, You-Jin Jeon, and Boo-Yong Lee. Inhibition of reactive oxygen species (ROS) and nitric oxide (NO) by Gelidium elegans with different drying and extraction conditions in 3T3-L1 and RAW 264.7 cells. Preventive Nutrition and Food Science, 17(2), 122-128, 2012

 

Young-Jun Lee, Bo-Ra Yoon, Hyeon-Son Choi, Boo-Yong Lee and Ok-Hwan Lee. Effect of Sargassum micracanthum extract on Lipid Accumulation and Reactive Oxygen Species (ROS) Production during Differentiation of 3T3-L1 Preadipocytes. Korean J Food Preserv., 19(3), 455-461,2012

 

Bo-Ra Yoon, Young-Jun Lee, Sun-Gu Kim, Jung-Young Jang, Hyo-Ku Lee, Seong-Kap Rhee, Hee-do Hong, Hyeon-Son Choi, Boo-Yong Lee and Ok-Hwan Lee. Antioxidant Effect of Hot water and Ethanol extracts from Cheonnyuncho (Opuntia humifusa) on Reactive Oxygen Species (ROS) Production in 3T3-L1 Adipocytes. Korean J Food Preserv., 19(3),443-450, 2012

 

Mi-Seon Woo, yeon-SonChoi,Ok-Hwan Lee, and Boo-Yong Lee. The edible red alga, Gracilariaverrucosa, inhibits lipid accumulation and ROS production, but improves glucose uptake, in3 T3-L1 cells. Phytotherapy Research, DOI: 10.1002/ptr.4813, 2012

 

Yi-Hong Kwon, Jun-Hee Lee, Seok-Yun Jung, Jae-Won Kim, Sang-Hun Lee, Dong-Hyung Lee, Kyu-Sup Lee, Boo-Yong Lee* ,and Sang-Mo Kwon*. Phloroglucinol inhibits the in vitro differentiation potential of CD34 positive cells into endothelial progenitor cells. Biomolecules &Therapeutics, 20(2), 158-164,2012

 

Bo-Ra Yoon, Bong-Jae Cho, Hyo-ku Lee, Dae-Jung Kim, Seong-Kap Rhee, Hee-do Hong, Kyung-Tack Kim, Chang-Won Cho, Hyeon-Son Choi, Boo-Yong Lee and Ok-Hwan Lee.
Antioxidant and Anti-Adipogenic Effects of Ethanolic Extracts from Tartary and Common Buckwheats. Korean J Food Preserv., 19(1), 123-130,2012

 

Minh-Hien Hoang, Yaoyao Jia, Hee-jin Jun, Ji Hae Lee, Kwang-Yeon Hwang, Dal-Woong Choi, Soo-Jong Um, Boo-Yong Lee, Sang-Guan You and Sung-Joon Lee. Taurine is a liver X receptor-α ligand and activates transcription of key genes in the reverse cholesterol transport without inducing hepatic lipogenesis. Molecular Nutrition & Food Research, 56(6),900-911,2012

 

Kui-Jin Kim, Kye-Yoon Yoon, and Boo-Yong Lee. Low Molecular Weight Fucoidan from the Sporophyll Undaria pinnatifida Suppresses Inflammation by Promoting the Inhibition of Mitogen-activated Protein Kinases and Oxidative Stress in RAW264.7 Cells. Fitoterapia, 83(8),1628–1635,2012

 

Kui-Jin Kim, Kye-Yoon Yoon, and Boo-Yong Lee. Fucoidan regulate blood glucose homeostasis in C57BL/KSJ m+/+db and C57BL/KSJ db/db mice. Fitoterapia, 83(6),1105–1109,2012

 

Min-Jung Seo, Hyeon-Son Choi, Ok-Hwan Lee, and Boo-Yong Lee. Grateloupia lanceolata (Okamura) Kawaguchi, the edible red seaweed, inhibits lipid accumulation and reactive oxygen species production during differentiation in 3T3-L1 cells. Phytotherapy Research, DOI: 10.1002/ptr.4765, 2012

 

Kui-Jin Kim, and Boo-Yong Lee. Fucoidan from the sporophyll of Undaria pinnatifida suppresses adipocyte differentiation via inhibition of inflammation-related cytokines in 3T3-L1 cells. Nutrition Research, 10.1016/j.nutres.2012.04.003, 2012

 

Kui-Jin Kim, Yoon-Kye Yoon, Hee-Do Hong, and Boo-Yong Lee. Schisandra chinensis defense against hepatic lipid peroxidation and oxidative stress in rats subjected to heat environmental stress. Phytotherapy Research, 26(11), 1674–-1680,2012

 

Yi-Hong Kwon, Seok-Yun Jung, Jae-Won Kim, Sang-Hun Lee, Jun-Hee Lee, Boo-Yong Lee* ,and Sang-Mo Kwon* Phloroglucinol inhibits the bioactivities of endothelial progenitor cells and suppresses tumor angiogenesis in LLC-tumor-bearing mice. PLoS ONE, 7(4),e33618,2012

 

Jae-Won Kim, Seok-Yun Jung, Yi-Hong Kwon, Sang-Hun Lee, Jun-Hee Lee,Boo-Yong Lee and Sang-Mo Kwon. Ginsenoside Rg3 Inhibits Endothelial Progenitor Cell Differentiation through Attenuation of VEGF-Dependent Akt/eNOS Signaling. Phytotherapy Research, DOI: 10.1002/ptr.3722, 2012

 

Jae-Won Kim, Seok-Yun Jung, Yi-Hong Kwon, Sang-Hun Lee, Zun-Hee Lee, Boo-Yong Lee* and Sang-Mo Kwon. Ginsenoside Rg3 attenuates tumor angiogenesis via inhibiting bioactivities of endothelial progenitor cells. Cancer Biology and Therapy, 13(7),504 – 515,2012

 

Hyojung Lee, Eui-joon Lee, Hyunseong Kim, Gihyun Lee, Sung-Hoon Kim, Boo-Yong Lee, Hyunsu Bae. Bee Venom-Associated Th1/Th2 Immunoglobulin Class Switching Results in Immune Tolerance of NZB/W F1 Murine Lupus Nephritis. American Journal of Nephrology, 34(2):163-172, 2011

 

Han-Bin Cho, Hee-Hyun Lee, Ok-Hwan Lee, Hyeon-Son Choi, Jae-Suk Choi, and Boo-Yong Lee. Clinical and microbial evaluation of the effects on gingivitis of a mouth rinse containing an Enteromorpha linza (E. linza) extract. Journal of Medicinal Food, accepted, 2011

 

Ok-Hwan Lee, Min-Jung Seo, Hyeon-Son Choi, and Boo-Yong Lee. Pycnogenol® inhibits lipid accumulation in 3T3-L1 adipocytes with the modulation of reactive oxygen species (ROS) production associated with antioxidant enzyme responses. Phytotherapy Research, DOI: 10.1002/ptr.3568, 2011

 

Kui-Jin Kim, Ok-Hwan Lee, and Boo-Yong Lee. Low molecular weight fucoidan regulates myogenic differentiation through the mitogen-activated protein kinase pathway in C2C12 cells. British Journal of Nutrition, doi:10.1017/S0007114511002534, 2011

 

Seong-Il Lim, Ki-Seung Seong, Sun-Mi Song, Jin-Taek Hwang, and Boo-Yong Lee. Effect of Rice Bran and Soybean Fermented by Bacillus spp. on Lipid Profiles of Liver, Serum, and Feces in Rats Fed High Fat Diet. J.Korean Soc. Appl. Biol. Chem., 54(2): 237-242, 2011

 

Ok-Hwan Lee, Kye-Yoon Yoon, Kui-Jin Kim, SangGuan You, and Boo-Yong Lee. Seaweed Extracts as a Potential Tool for the Attenuation of Oxidative Damage in Obesity-Related Pathologies. Journal of Phycology, 47(3):548-556, 2011

 

Sung Kwon Ko, Ok Sun Cho, Hye Min Bae, Byung Ok Im, Ok-Hwan Lee, and Boo-Yong Lee. Quantitative Analysis of Ginsenosides Composition in Flower Buds of Various Ginseng Plants. J.Korean Soc. Appl. Biol. Chem., 54(1):154-157, 2011

 

MyoungLae Cho, Boo-Yong Lee* and SangGuan You. Relationship between Oversulfation and Conformation of Low and High Molecular Weight Fucoidans and Evaluation of Their in vitro Anticancer Activity. Molecules, 16(1):291-297, 2011

 

Ok-Hwan Lee, Hee-Hyun Lee, Ji-Hyup Kim and Boo-Yong Lee. Effect of ginsenosides Rg3 and Re on glucose transport in mature 3T3-L1 adipocytes. Phytotherapy Research, 25(5):768–773, 2011

 

Seong-Il Lim, Eun-Jung Kwak, Ok-Hwan Lee, and Boo-Yong Lee. Effect of Antibrowning Agents on Browning and Intermediate Formation in the Glucose–Glutamic Acid Model. Journal of Food Science, 75(8):C678-C683, 2010

 

Kim BH, Casimir C. Akoh, Lee BY. The Effects of High Dietary Lard on Hypertension Development in Spontaneously Hypertensive Rats. Journal of Medicinal Food 13(4): 1-10, 2010

 

Kim SH, Hyun SH, Yang SO, Choi HK, Lee BY. 1H NMR-Based Discrimination of Thermal and Vinegar Treated Ginseng Roots. Journal of Food Science 75(6): C577-C581, 2010

 

Kim KJ, Hong HD, Lee OH, Lee BY. The effects of Acanthopanax senticosus on global hepatic gene expressionin rats subjected to heat environmental stress. Toxicology doi:10.1016/j.tox.2010.04.010, 2010

 

Kim KJ, Lee OH, Lee BY. Fucoidan, sulfated polysaccharide, inhibits adipogenesis through the mitogen-activated protein kinase pathway in 3T3-L1 preadipocytes. Life Sciences 86: 791-797, 2010

 

Lee HH, Kim KJ, Lee OH, Lee BY. Effect of Pycnogenol on Glucose Transport in Mature 3T3-L1 Adipocytes. Phytotherapy Research 24: 1242–1249, 2010

 

Lim SI, Lee BY. Anti-Diabetic Effect of Material Fermented Using Rice Bran and Soybean as the Main Ingredient by Bacillus sp. J.Korean Soc. Appl. Biol. Chem 53(2): 222-229, 2010

 

Lim SI, Lee BY. Effect of the Licorice (Glycyrrhiza glabra) Ethanol Extract on Growth of Bacillus cereus at the Meju Producing Stage. J.Korean Soc. Appl. Biol. Chem 53(2): 184-191, 2010

 

Kwak KW, Cho KS, Hahn OJ, Lee KH, Lee BY, Ko JJ, Chung KH. Biological effects of fucoidan isolated from Fucus vesiculosus on thrombosis and vascular cells. The Korean Journal of Hematology 45(1): 51-57, 2010

 

Kim KJ, Lee OH, Lee BY. Genotoxicity studies on Fucoidan from Sporophyll of Undaria Pinnatifida. Food and Chemical Toxicology 48: 1101-1104, 2010

 

Lee HM, Lee OH, Lee BY. Effect of Ginsenoside Rg3 and Rh2 on Glucose Uptake in Insulin-resistant Muscle Cells. J.Korean Soc. Appl. Biol. Chem. 53(1): 106-109, 2010

 

Lee OH, Lee BY. Antioxidant and Antimicrobial Activities of Individual and Combined Phenolics in Olea europaea Leaf Extract. Bioresource Technology 101(10): 3751-3754, 2010

 

Lee CH, Choi JH, Yoo KY, Park OK, Hwang IK, You SG, Lee BY, Kang IJ, Won MH. MT2 melatonin receptor immunoreactivity in neurons is very high in the aged hippocampal formation in gerbils. CELL MOL. NEUROBIOL 30(2): 255-263, 2010

 

Kim KJ, Lee OH, Lee HH, Lee BY. A 4-week repeated oral dose toxicity study of fucoidan from the Sporophyll of Undaria pinnatifida in Sprague-Dawley rats. Toxicology 267: 154-158, 2010

 

You SG, Yang C, Lee HY, Lee BY. Molecular characteristics of partially hydrolyzed fucoidans from sporophyll of Undaria Pinnatifida and their in vitro anticancer activity. Food Chemistry 119: 554-559, 2010

 

Lee YM, Lim DY, Choi HJ, Seon MR, Kim JK, Lee BY, Park JHY. Piceatannol, a natural stilbene from grapes, induces G1 cell cycle arrest in androgen-insensitive DU145 human prostate cancer cells via the inhibition of CDK activity. Cancer Letters 285: 166-173: 2009

 

Kang HJ, Ko KW, Lee OH, and Lee BY. Antioxidant, Antimicrobial, and Cancer Cell Proliferative Inhibition Activities of Propolis. Food Science and Biotechnology 18(4): 1042-1045, 2009

 

Lee OH, Lee BY, Lee JS, Lee HB, Son JY, Park CS, Kalidas Shetty, Kim YC. Assessment of phenolics-enriched extract and fractions of olive leavesand their antioxidant activities. Bioresource Technology 100(23): 6107-6113, 2009

 

Ko KW, Kang HJ, Lee BY. Antioxidant, Antimicrobial, and Antiproliferative activities of Olive (Olea europaea L.) Leaf Extracts. Food Science and Biotechnology 18(3): 818-821, 2009

 

Ko SK, Cho OS, Bae HM, Sohn UD, Im BO, Cho SH, Chung SH, Lee BY. Change of Ginsenoside Composition of Various American Ginseng Roots. J.Korean Soc. Appl. Biol. Chem. 52(2): 198-201, 2009

 

Hyung-Sun Youn, Sang-Il Ahn, Boo-Yong Lee. Guggulsterone suppresses the activation of transcription factor  IRF3 induced by TLR3 or TLR4 agonists. International Immunopharmacology, 9(1),108-112, 2009

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[저서]

-식품영양실험핸드북. 이부용외 다수. 한국식품영양과학회 출판. 2000.10.30
-Korean Functional Foods. Boo Yong Lee etc., CRC Press. 2018.5
– 영양과 건강(e-Book). 박선민,이부용,황권택. ISBN: 979-11-8847-64-8(95510). 2020